Chronic cerebral hypoperfusion accelerates amyloid β deposition in APPSwInd transgenic mice
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چکیده
منابع مشابه
Chronic cerebral hypoperfusion accelerates amyloid beta deposition in APPSwInd transgenic mice.
Chronic cerebral ischemia may accelerate clinicopathological changes in Alzheimer's disease. We have examined whether chronic cerebral hypoperfusion accelerates amyloid beta deposition in amyloid protein precursor transgenic (APP-Tg) mouse. At 5, 8, and 11 months of age, C57Bl/6J male mice overexpressing a mutant form of the human APP bearing the both Swedish (K670N/M671L) and the Indiana (V717...
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From the Experimental Genetics Group,* Center for Human Genetics, Flemish Institute for Biotechnology, the Center for Transgene Technology and Gene Therapy, Center for Molecular and Vascular Biology, and Genetic Epidemiology, K.U.Leuven, Leuven, Belgium; the Janssen Research Foundation, Beerse, Belgium; Innogenetics, Gent, Belgium; Institut de Pharmacology Moléculaire et Cellulaire/CNRS, Valbon...
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ژورنال
عنوان ژورنال: Brain Research
سال: 2009
ISSN: 0006-8993
DOI: 10.1016/j.brainres.2009.07.078